Formulation in Pharmacy Practice  eMixt

Gabapentin
 
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Gabapentin is freely soluble in water and both basic and acidic aqueous solutions.

 

New Zealand
A New Zealand standardised formula is available Formula and Batch Sheet
This formula uses Ora-Blend or Ora-Plus and Ora-Sweet in equal parts, and has been approved by the Extemporaneous Compounding Pharmacists' Group.

International
As above; details of alternatives given below.


Formula 1

Gabapentin 250mg per 5mL
 
Gabapentin Capsules 250mg 20 
Methylcellulose 1% 50  mL
*Parabens 0.1  %
#Syrup to   100  mL
* Suggested addition as an antimicrobial preservative.
# If required, replace syrup with glycerol
Expiry:  30 days at 4 - 25°C
Stability:   91 days at 4°C; 56 days at 25°C
 

 
Note
  1. Gabapentin is also stable when capsule contents are suspended in a 1:1 mixture of Ora-Sweet:Ora-Plus.1
Reference
  1. Nahata M.C.  Stability of gabapentin in extemporaneously prepared suspensions at two temperatures.  Pediatr Neurol 1999; 20 (3): 195-7.

 
Formulation in Pharmacy Practice
Page Updated July 2013